Current status of sevoflurane anesthesia in association with microglia inflammation and neurodegenerative diseases

Sevoflurane is one of the most commonly used volatile anesthetics in clinical practice and often pediatric anesthesia intraoperative maintenance. Microglia exist central nervous system are innate immune cells system. Under external stimulation, microglia divided into two phenotypes: proinflammatory (M1 type) anti-inflammatory (M2 type), maintaining stability through induction, housekeeping, defense functions. can activate microglia, increase expression inflammatory factors various signaling pathways, release mediators to cause oxidative stress, damage nerve tissues, eventually develop neurodegenerative diseases. In this article, relationship between sevoflurane inflammation occurrence diseases reviewed as follows.